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Hito en la medicina: en Estados Unidos hicieron un inédito trasplante de riñón de cerdo a un humano

Un hospital estadounidense informó que un equipo de cirujanos realizó un inédito trasplante de un riñón de un cerdo genéticamente modificado a un humano.

El paciente, un hombre de 62 años, "se recupera bien" de la operación, que se llevó a cabo el sábado pasado, anunció el Hospital General de Massachusetts, en Boston, en un comunicado. Según informaron, toda la cirugía duró unas cuatro horas.

Ya se habían trasplantado riñones de cerdo a personas en muerte cerebral. En el pasado pacientes conscientes también recibieron un trasplante de corazón de un cerdo genéticamente modificado, pero fallecieron.

Las modificaciones genéticas se llevan a cabo para reducir el riesgo de rechazo por parte de los receptores. Los cerdos son de los animales con mayor compatibilidad respecto a los seres humanos.

Los médicos "me explicaron minuciosamente los pros y los contras del procedimiento", afirmó el paciente, Richard Slayman, citado en el comunicado. "Lo vi como una manera no sólo de ayudarme a mí, sino también de dar esperanza a miles de personas que necesitan un trasplante para sobrevivir", remarcó.

El hombre, que vive en el estado de Massachusetts, evaluó los pro y contras con el equipo médico y tomó la decisión de operarse con la esperanza de "no solo mejorar su calidad de vida, si no también de extenderla". Según el diario The Independent. Slayman había comenzado a tener problemas con su riñón en 2023.

Más de 100.000 personas esperan un trasplante de órgano en Estados Unidos, sobre todo de riñón, según datos oficiales de la oficina que coordina la donación en ese país (UNOS). De acuerdo a información citada por el diario Boston Herald, desde UNOS estiman que las enfermedades en dicho órgano podrían crecer entre un 29 y un 68 por ciento para 2030.

En Argentina, en 2022 se realizaron 4.264 trasplantes según datos del INCUCAI. De todos ellos, 1.534 fueron de riñón y 26 de riñón e hígado en conjunto.

El campo de los xenoinjertos (trasplantes de órganos de animales a humanos) ha avanzado a gran velocidad en los últimos años. Es un tipo de recurso que ya había imaginado René Favaloro durante la década del 90, cuando todavía estaba lejísimos esa posibilidad.

El trabajo de edición fue realizado por la firma eGenesis, una empresa de biotecnología de Massachusetts que utilizó tijeras CRISPR-Cas9 para sustituir los genes dañinos del cerdo y por genes humanos específicos, con el fin de hacerlo compatible con el cuerpo humano.

Estas tijeras que "cortan el ADN" son una de las grandes revoluciones del campo genético de la última década. Se trata de un componente líquido que actúa en dos pasos. La primera detectando el ADN y luego produciendo el corte específico de un gen para dejar que no se exprese o introducir un tipo de gen nuevo. En el caso del órgano para el trasplante, debieron hacer 69 cortes.

En septiembre de 2021, cirujanos del hospital Langone de Nueva York llevaron a cabo el primer trasplante mundial de riñón de cerdo a una persona en muerte cerebral. Fue un procedimiento pionero para este hito que se logró ahora.

Fuente: AS

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  • SELECT `a`.`id`,`a`.`title`,`a`.`catid`,`a`.`language`, CASE WHEN CHAR_LENGTH(`a`.`alias`) != 0 THEN CONCAT_WS(':', `a`.`id`, `a`.`alias`) ELSE a.id END AS `slug`, CASE WHEN CHAR_LENGTH(`cc`.`alias`) != 0 THEN CONCAT_WS(':', `cc`.`id`, `cc`.`alias`) ELSE cc.id END AS `catslug` FROM `wkdtf_content` AS `a` LEFT JOIN `wkdtf_categories` AS `cc` ON `cc`.`id` = `a`.`catid` WHERE `a`.`catid` = :catid AND `a`.`state` = :state AND `a`.`access` IN (:preparedArray1,:preparedArray2) AND (`publish_up` IS NULL OR `publish_up` <= :nowDate1) AND (`publish_down` IS NULL OR `publish_down` >= :nowDate2) ORDER BY CASE WHEN `a`.`publish_up` IS NULL THEN `a`.`created` ELSE `a`.`publish_up` END DESC353μs1.77KBParams/plugins/content/pagenavigation/src/Extension/PageNavigation.php:188Copy
  • SELECT `c`.`id`,`c`.`asset_id`,`c`.`access`,`c`.`alias`,`c`.`checked_out`,`c`.`checked_out_time`,`c`.`created_time`,`c`.`created_user_id`,`c`.`description`,`c`.`extension`,`c`.`hits`,`c`.`language`,`c`.`level`,`c`.`lft`,`c`.`metadata`,`c`.`metadesc`,`c`.`metakey`,`c`.`modified_time`,`c`.`note`,`c`.`params`,`c`.`parent_id`,`c`.`path`,`c`.`published`,`c`.`rgt`,`c`.`title`,`c`.`modified_user_id`,`c`.`version`, CASE WHEN CHAR_LENGTH(`c`.`alias`) != 0 THEN CONCAT_WS(':', `c`.`id`, `c`.`alias`) ELSE `c`.`id` END as `slug` FROM `wkdtf_categories` AS `s` INNER JOIN `wkdtf_categories` AS `c` ON (`s`.`lft` <= `c`.`lft` AND `c`.`lft` < `s`.`rgt`) OR (`c`.`lft` < `s`.`lft` AND `s`.`rgt` < `c`.`rgt`) WHERE (`c`.`extension` = :extension OR `c`.`extension` = 'system') AND `c`.`access` IN (:preparedArray1,:preparedArray2) AND `c`.`published` = 1 AND `s`.`id` = :id ORDER BY `c`.`lft`452μs3.91KBParams/libraries/src/Categories/Categories.php:375Copy
  • SELECT `params` FROM `wkdtf_categories` WHERE `id`=2117μs536B/libraries/astroid/framework/library/astroid/Article.php:631Copy
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  • SELECT `enabled` FROM `wkdtf_extensions` WHERE `element` = 'astroid' AND `type` = 'library'93μs536B/plugins/system/jollyany/jollyany.php:1194Copy
  • SELECT `m`.`id`,`m`.`title`,`m`.`module`,`m`.`position`,`m`.`content`,`m`.`showtitle`,`m`.`params`,`mm`.`menuid` FROM `wkdtf_modules` AS `m` LEFT JOIN `wkdtf_modules_menu` AS `mm` ON `mm`.`moduleid` = `m`.`id` LEFT JOIN `wkdtf_extensions` AS `e` ON `e`.`element` = `m`.`module` AND `e`.`client_id` = `m`.`client_id` WHERE ( ( (`m`.`published` = 1 AND `e`.`enabled` = 1 AND `m`.`client_id` = :clientId AND `m`.`access` IN (:preparedArray1,:preparedArray2)) AND (`m`.`publish_up` IS NULL OR `m`.`publish_up` <= :publishUp)) AND (`m`.`publish_down` IS NULL OR `m`.`publish_down` >= :publishDown)) AND (`mm`.`menuid` = :itemId OR `mm`.`menuid` <= 0) ORDER BY `m`.`position`,`m`.`ordering`989μs2KBParams/libraries/src/Cache/Controller/CallbackController.php:51Copy
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  • SELECT `alias` FROM `wkdtf_content` WHERE `id` = :id71μs1.31KBParams/components/com_content/src/Service/Router.php:168Copy
  • SELECT * FROM wkdtf_hikashop_config551μs24.63KB/administrator/components/com_hikashop/classes/config.php:16Copy
  • SET sql_mode=(SELECT REPLACE(REPLACE(@@sql_mode,'ONLY_FULL_GROUP_BY',''), 'STRICT_TRANS_TABLES', ''));52μs0B/administrator/components/com_hikashop/helpers/helper.php:3532Copy
  • SELECT cart.cart_id FROM wkdtf_hikashop_cart AS cart WHERE (cart.cart_type = 'cart') AND (cart.session_id = 'cd268c1329fd66e9fb05fd9cc87400d4') ORDER BY cart.cart_current DESC, cart.cart_modified DESC121μs520B/administrator/components/com_hikashop/classes/cart.php:69Copy
  • SELECT a.id FROM wkdtf_menu AS a INNER JOIN `wkdtf_menu_types` as b on a.menutype = b.menutype WHERE a.type='component' AND a.published=1 AND b.title IS NOT NULL AND a.access IN (1,5) AND a.client_id=0 AND a.link='index.php?option=com_hikashop&view=checkout&layout=show' AND a.language IN ('*', '', 'es-ES')287μs520B/administrator/components/com_hikashop/classes/menus.php:323Copy
  • SELECT a.id FROM wkdtf_menu AS a INNER JOIN `wkdtf_menu_types` as b on a.menutype = b.menutype WHERE a.type='component' AND a.published=1 AND b.title IS NOT NULL AND a.access IN (1,5) AND a.client_id=0 AND a.link LIKE 'index.php?option=com_hikashop&view=%' AND a.language IN ('*', '', 'es-ES')224μs520B/administrator/components/com_hikashop/classes/menus.php:323Copy
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  • SELECT e.manifest_cache,`e`.`manifest_cache` FROM `wkdtf_extensions` AS `e` WHERE `e`.`element` = 'com_sppagebuilder'188μs592B/administrator/components/com_sppagebuilder/helpers/sppagebuilder.php:81Copy
  • SELECT enabled FROM `wkdtf_extensions` WHERE `name` = 'com_easystore'283μs520B/administrator/components/com_sppagebuilder/editor/helpers/ApplicationHelper.php:138Copy
  • SELECT `template` FROM `wkdtf_template_styles` WHERE `client_id` = 0 AND `home` = 1168μs536B/components/com_sppagebuilder/builder/classes/base.php:87Copy
  • SELECT DISTINCT a.id, a.title, a.level, a.published, a.lft, a.parent_id FROM ( SELECT id,title,level,published,parent_id,lft,rgt FROM wkdtf_tags WHERE `published` = '1') AS a LEFT JOIN `wkdtf_tags` AS b ON a.lft > b.lft AND a.rgt < b.rgt WHERE `a`.`level` != '0' ORDER BY a.lft ASC324μs816B/components/com_sppagebuilder/builder/classes/base.php:372Copy
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  • SELECT DISTINCT a.id, a.title, a.level, a.published, a.lft, a.parent_id FROM ( SELECT id,title,level,published,parent_id,lft,rgt FROM wkdtf_tags WHERE `published` = '1') AS a LEFT JOIN `wkdtf_tags` AS b ON a.lft > b.lft AND a.rgt < b.rgt WHERE `a`.`level` != '0' ORDER BY a.lft ASC233μs816B/components/com_sppagebuilder/builder/classes/base.php:372Copy
  • SELECT a.enabled FROM `wkdtf_extensions` AS `a` WHERE `a`.`name` = 'com_k2'258μs520B/components/com_sppagebuilder/builder/classes/base.php:960Copy
  • SELECT a.enabled FROM `wkdtf_extensions` AS `a` WHERE `a`.`name` = 'com_k2'224μs520B/components/com_sppagebuilder/builder/classes/base.php:960Copy
  • SELECT DISTINCT a.id, a.title, a.level, a.published, a.lft, a.parent_id FROM ( SELECT id,title,level,published,parent_id,lft,rgt FROM wkdtf_tags WHERE `published` = '1') AS a LEFT JOIN `wkdtf_tags` AS b ON a.lft > b.lft AND a.rgt < b.rgt WHERE `a`.`level` != '0' ORDER BY a.lft ASC329μs816B/components/com_sppagebuilder/builder/classes/base.php:372Copy
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  • SELECT e.manifest_cache,`e`.`manifest_cache` FROM `wkdtf_extensions` AS `e` WHERE `e`.`element` = 'com_sppagebuilder'168μs592B/components/com_sppagebuilder/helpers/helper.php:2028Copy
  • SELECT e.manifest_cache,`e`.`manifest_cache` FROM `wkdtf_extensions` AS `e` WHERE `e`.`element` = 'com_sppagebuilder'172μs592B/components/com_sppagebuilder/helpers/helper.php:2028Copy
  • SELECT e.manifest_cache,`e`.`manifest_cache` FROM `wkdtf_extensions` AS `e` WHERE `e`.`element` = 'com_sppagebuilder'144μs592B/components/com_sppagebuilder/helpers/helper.php:2028Copy
  • SELECT `a`.`name`,`a`.`css_path` FROM `wkdtf_sppagebuilder_assets` AS `a` WHERE `a`.`published` = 1132μs576B/components/com_sppagebuilder/helpers/helper.php:2059Copy
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  • SELECT e.manifest_cache,`e`.`manifest_cache` FROM `wkdtf_extensions` AS `e` WHERE `e`.`element` = 'com_sppagebuilder'168μs592B/components/com_sppagebuilder/helpers/helper.php:2028Copy
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  • SELECT * FROM `wkdtf_sppagebuilder` WHERE `extension` = 'mod_sppagebuilder' AND `extension_view` = 'module' AND `view_id` = '111'538μs139KB/modules/mod_sppagebuilder/helper.php:49Copy
  • SELECT e.manifest_cache,`e`.`manifest_cache` FROM `wkdtf_extensions` AS `e` WHERE `e`.`element` = 'com_sppagebuilder'177μs592B/administrator/components/com_sppagebuilder/helpers/sppagebuilder.php:81Copy
  • SELECT enabled FROM `wkdtf_extensions` WHERE `name` = 'com_easystore'266μs520B/administrator/components/com_sppagebuilder/editor/helpers/ApplicationHelper.php:138Copy
  • SELECT `template` FROM `wkdtf_template_styles` WHERE `client_id` = 0 AND `home` = 1122μs536B/components/com_sppagebuilder/builder/classes/base.php:87Copy
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  • SELECT e.manifest_cache,`e`.`manifest_cache` FROM `wkdtf_extensions` AS `e` WHERE `e`.`element` = 'com_sppagebuilder'124μs592B/components/com_sppagebuilder/helpers/helper.php:2028Copy
  • SELECT e.manifest_cache,`e`.`manifest_cache` FROM `wkdtf_extensions` AS `e` WHERE `e`.`element` = 'com_sppagebuilder'89μs592B/components/com_sppagebuilder/helpers/helper.php:2028Copy
  • SELECT e.manifest_cache,`e`.`manifest_cache` FROM `wkdtf_extensions` AS `e` WHERE `e`.`element` = 'com_sppagebuilder'86μs592B/components/com_sppagebuilder/helpers/helper.php:2028Copy
  • SELECT `a`.`name`,`a`.`css_path` FROM `wkdtf_sppagebuilder_assets` AS `a` WHERE `a`.`published` = 164μs576B/components/com_sppagebuilder/helpers/helper.php:2059Copy
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  • SELECT e.manifest_cache,`e`.`manifest_cache` FROM `wkdtf_extensions` AS `e` WHERE `e`.`element` = 'com_sppagebuilder'89μs592B/components/com_sppagebuilder/helpers/helper.php:2028Copy
  • SELECT `template` FROM `wkdtf_template_styles` WHERE `client_id` = 0 AND `home` = 1125μs536B/components/com_sppagebuilder/builder/classes/base.php:87Copy
  • SELECT `template` FROM `wkdtf_template_styles` WHERE `client_id` = 0 AND `home` = 1129μs536B/components/com_sppagebuilder/builder/classes/base.php:87Copy
  • SELECT `name`,`element` FROM `wkdtf_extensions` WHERE `type` = 'plugin' AND `folder` = 'finder' AND `enabled` = 1330μs656B/administrator/components/com_finder/src/Helper/LanguageHelper.php:134Copy
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  • SELECT `a`.`name`,`a`.`css_path` FROM `wkdtf_sppagebuilder_assets` AS `a` WHERE `a`.`published` = 167μs576B/components/com_sppagebuilder/helpers/helper.php:2059Copy
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